活性抗體丨Rac-GTP 小鼠單抗丨**期刊文獻

時間：2023-01-04作者：武漢費斯德生物科技有限公司瀏覽：238

品牌: 美國 NewEast Biosciences
貨號: 26903
抗原: Full Recombinant Active Rac
規(guī)格: 30 微升
產(chǎn)品全名: Anti-Rac1-GTP Monoclonal Antibody
應用: IP, IHC, IF
種屬反應性的選擇: Human, Mouse and Rat
物種/宿主: Mouse

近期文獻：

001.Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles J Cell Commun Signal. 2022??PMID: 36508052

002.Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine **ing Mol Biol Cell. 2022??PMID: 35653297

003.Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice Cell Death Discov. 2022??PMID: 35031595

004.Smooth muscle Rac1 contributes to pulmonary hypertension BJP. 2022??PMID: 35064565

005.Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification Cardiovasc Pathol. 2022??PMID: 35074515

006.A Portable Controllable Compressive Stress Device to Monitor Human Breast Cancer Cell Protrusions at Single-Cell Resolution J Clin Invest. 2022??PMID: 35104805

007.Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition – More Than Just ROS-inhibition J Clin Transl Hepatol. 2022??PMID: 35233372

008.Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension J Neuroinflammation. 2022??PMID: 35284404

009.Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells Development. 2022??PMID: 35420656

010.Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats Front Mol Neurosci. 2022??PMID: 35782392

011.Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor Front Bioeng Biotechnol. 2022??PMID: 35831873

012.ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42 J Exp Clin Cancer Res. 2022??PMID: 35869555

anoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery Sci Adv. 2022??PMID:  36129975

014.Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation Nat Commun. 2022??PMID:  36130971

015.The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner Biomolecules. 2022??PMID: 36139020

016.Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage Cell Death Dis. 2022??PMID: 36229446

017.Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis J Cell Commun Signal. 2022??PMID: 36284029

018.PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate Biomolecules. 2022??PMID: 36291720

019.Dock4 is required for the maintenance of cochlear hair cells and hearing function Fundamental Research. 2022 背景介紹:   Small GTPases are a super-family of cellular **ing regulators. Rac belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Rac, and the hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase activating proteins (s), while exchange of GDP for GTP is facilitated by nine nucleotide exchange factors (GEFs). *原:   Recombinant full length protein of active Rac1 經(jīng)過測試的應用:   IP, IHC, IF 推薦稀釋比: IP: 1 μg for 1~2 mg total cellular proteins IHC, IF: 1:50-1:250 濃度:   1 mg/ml *沉淀/蛋白質(zhì)印跡:   Rac Activation Assay. MEF cells were treated with (lane 2) or without (lane 1) PDGF. Cell lysates were incubated with an anti-Rac-GTP monoclonal antibody (Cat. # 26903) (top panel). Th precipitated active Rac was immunoblotted with an anti-Rac rabbit polyclonal antibody (Cat. # 21003). The bottom panel shows the Western blot with anti-Rac of the cell lysates used (5% of that used in the top panel). *熒光:   Immunofluorescence for the active Rac using Anti-Rac1-GTP Mouse Monoclonal Antibody [26903] shows Rac-GTP immunolabeling (green) in combination with cofilin (red) on brain tissue sections. The tissue sections were fixed with -20 oC methanol or 4% paraformaldehyde (fixation time 1 hr) and stained with antibody at 1: 1000 in 0.1M Phosphate buffer with 0.3% Triton X, and 4% BSA for 24h at room temperature. Secondary antibodies were anti-mouse AlexaFluor488 and anti-rabbit AlexaFluor594 at 1: 1000.


武漢費斯德生物科技有限公司專注于G蛋白活性抗體及試劑盒,非乙?；疌AMP和CGMP試劑,點突變抗體等

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  GTP酶是GTP/GDP結合蛋白。被細胞表面受體(GPCR)后, 它能調(diào)節(jié)下游效應器的功能。它可以結合GTP、水解GTP，因此在的GTP結合狀態(tài)和非的GDP結合狀態(tài)之間切換。它具有內(nèi)在的GTP酶活性，可將GTP水解為GDP，從而使G蛋白失活。我們精心篩選的小鼠單抗體能捕捉到與GTP結合的具有活性的GTP酶。它們已被用于通過*組織化學監(jiān)測細胞和組織中 G 蛋白的活化和分布。001. The Sca